Liver resection in the setting of obesity.
O'Connell, Robert M; Hoti, Emir
An estimated 2.5 billion adults are classified as overweight or obese globally, a figure that has risen rapidly over the last number of decades (1). Deaths and disability related to high body mass index (BMI) have increased more than 2.5-fold since 1990, with the sharpest rise seen in low- and middle-income countries (2). A proportion of 3.6% of all new cancer cases, and 4.6% of all cancer deaths are attributable to high BMI globally (3). As a result of the obesity epidemic, and of the resultant metabolic syndrome, the prevalence of non-alcoholic fatty liver disease (NAFLD) is now 30% worldwide, with Latin America and Middle East-North Africa experiencing the highest rates (4). Obesity is a significant risk factor not only in the development of primary malignancy of the liver, chiefly hepatocellular carcinoma (HCC), but also for colorectal cancer and colorectal liver metastases (CRLM) (5,6).
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