Hyperparathyroidism Is an Independent Risk Factor for Allograft Dysfunction in Pediatric Kidney Transplantation.
Prytula, Agnieszka; Shroff, Rukshana; Krupka, Kai; Deschepper, Ellen; Bacchetta, Justine; Ariceta, Gema; Awan, Atif; Benetti, Elisa; Büscher, Anja; Berta, László; Carraro, Andrea; Christian, Martin; Dello Strologo, Luca; Doerry, Katja; Haumann, Sophie; Klaus, Guenter; Kempf, Caroline; Kranz, Birgitta; Oh, Jun; Pape, Lars; Pohl, Martin; Printza, Nikoleta; Rubik, Jacek; Schmitt, Claus Peter; Shenoy, Mohan; Spartà, Giuseppina; Staude, Hagen; Sweeney, Clodagh; Weber, Lutz; Weber, Stefanie; Weitz, Marcus; Haffner, Dieter; Tönshoff, Burkhard
This registry study from the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) collected data at baseline, months 1, 3, 6, 9, and 12 after transplant; and every 6 months thereafter up to 5 years. Survival analysis for a composite end point of graft loss or estimated glomerular filtration rate (eGFR) ≤30 ml/min per 1.73 m2 or a ≥50% decline from eGFR at month 1 posttransplant was performed. Associations of parathyroid hormone (PTH), calcium, phosphate, and 25-hydroxyvitamin D (25(OH)D) with allograft outcome were investigated using conventional stratified Cox proportional hazards models and further verified with marginal structural models with time-varying covariates.
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