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Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

Title: Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study. Authors: Hung, Chi-Fa; Rivera, Margarita; Craddock, Nick; Owen, Michael J; Gill, Michael; Korszun, Ania; Maier, Wolfgang; Mors, Ole; Preisig, Martin; Rice, John P; Rietschel, Marcella; Jones, Lisa; Middleton, Lefkos; Aitchison, Kathy J; Davis, Oliver S P; Breen, Gerome; Lewis, Cathryn; Farmer, Anne; McGuffin, Peter Abstract: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.

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