Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health.
Townsend, Liam; Dyer, Adam H; Naughton, Aifric; Kiersey, Rachel; Holden, Dean; Gardiner, Mary; Dowds, Joanne; O'Brien, Kate; Bannan, Ciaran; Nadarajan, Parthiban; Dunne, Jean; Martin-Loeches, Ignacio; Fallon, Padraic G; Bergin, Colm; O'Farrelly, Cliona; Cheallaigh, Cliona Ni; Bourke, Nollaig M; Conlon, Niall
The immunological and inflammatory changes following acute COVID-19 are hugely variable. Persistent clinical symptoms following resolution of initial infection, termed long COVID, are also hugely variable, but association with immunological changes has not been described. We investigate changing immunological parameters in convalescent COVID-19 and interrogate their potential relationships with persistent symptoms.
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